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Im a 204 guy but of your two choices they are alot the same. If Im not worring about fur I like the 243 better.

17 Rem is mentioned quite a bit. I have one and love it. That said, it was really windy so far this fall. I grab the wife's 243 when it's blowing. Come to think of it, it's windy here a lot Sept-Jan/Feb.

If you're in a windy region, opt for the 243.

P.S. It's been said before that the 17 Rem and 223 with comparable bullet weights (.224 40 gr?) drift pretty similarly out to 300 yards. Something to think on.

Here's my 17 Rem:

243 all the way.

You can run a higher BC 55gr at 4,000fps+, vs 3,700 in 22-250, and, when conditions call for it, a heavier bullet for longer ranges or bucking winds.

I use a 22 Hornet, 222Rem Mag or the 243, depending on conditions.

A guy I know is a retired Govt damage control officer or what ever they called it. He hunted feral dogs, cats and coyotes for a living for about 10 years. He uses a suppressed 243 shooting 55 grain Ballistic tips at 4100 fps +. He says that they don't exit which is important as he shot a lot of critters in town! I just picked up a box of 250 and to try them out.

Depends on what you want the gun to do. In my experience with a 243 if you shoot the heavy bullets like 100 grain sierra gamekings and 105 bergers the damage is minimal and is only an in and out with no significant exit damage. I built a 204 a couple years ago that i had throated and twisted to shoot the 55 grain bergers and its great in the wind and will shoot those at about 3250 out of a 24" barrel. This setup shoots well and and does minimal damage.

22-250 and 220 swift work extremely well and knock coyotes dead with authority but if you want to save the pelt bullet selection is critical.

22-250 all day long. Twisted appropriately, however.