With 150 I am using 62.2 grns of h1000 in my 24" barrel 280AI and getting 3040fps I can run faster but this load is easy on brass. Norma cases cci 250. Shoots under my thumb nail for five at 100 yards.
And then zeroing the new VX6 first 2 shots where low and left. I moved it over 1/4" and up 1/4 and shot four more.
This has been my results my bro uses 55 grns of RL 17 and 140 AB to the tune of 3150 fps.
A good friend of mine swears by h4831 for the 280 AI and he has had about 15 different one over the last 40 years.