After seeing misfires over the years, in addition to chambering every round before a hunt I also weigh every round.
For very large cartridges you may see an extreme spread of 3-5 grains(I don't normally separate brass by weight but do by lot #) however this will still clearly show if there is a mistake in powder charges such as no charge or a double charge. Been doing this for years, never a misfire. Knock on wood. (Ow :-)
Could save your skin someday if dangerous game is on the menu.

Just a tip I normally don't see but though I'd pass it along.

Last edited by Akhutr; 02/25/17.