I'll answer that....
You're in Virginia.
You have groundhogs, but not enough to melt your barrel, especially on Sundays (that's a dirty shame, by the way).
A 22-250 is actually probably better than a 223 given the size of the target and the rate of fire -- in Virginia.
But if you come out West to South Dakota and have a good guide and good shooting, or luck into a good ranch on a typical summer day, your 22-250 will start to droop.
I've had hunts where my 22-250 buddies had to sit and wait while I whaled away with the 223 -- especially when I used special Blue Dot loads that move a little bullet fast.
All that said, the ultimate varminter is the one that YOU like the best. I'm lucky in that I have several. Each is the "best" for the application at hand.
So the 22-250 is the perfect "core" gun for you, for others it's the .223, for others a six, or .204 --
Up hills slow,
Down hills fast
Tonnage first and