I used a 168 gr. TTSX handload at about 2700 fps two years ago on a 500 lb. cow with good results; behind the near shoulder and thru the off shoulder at a little over a hundred yds. Really tore up the lungs and dropped her after 20 yds. I think it probably could have been done with a lesser bullet, even a C&C, but I think the next time I get drawn I won't change a thing.
The man who thinks he can, and the man who thinks he can't, are both correct.