22-250,50 to 52 grain bullets ...i drive them as fast, as i can get them to land right.
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no, but I can speak real highly of AR Comp from Alliant...
and it runs some impressive velocities on top of being a tack driver and temp insensitive...

My friend has used the 8208 in .223 and ,22-250 with good results. Rifles that he couldn;t get to shoot well are shooting excellent groups with this powder. I don; thave his data in front of me, but his most accurate loads were at or approaching book max,

No, but Varget drives tacks for me in the .22-250 with 55gr Blitzkings @3700+.

I have been curious about the 8208 and how it compares to Varget.

Works great in 22-250, 338 Federal, and 204 for me. I like Hodgdon's powders and this one gives top performance with several of the calibers I shoot alot. Also works well in the 17FB, giving over 3800FPS with 25gr Horn HP's. T.S.

Works pretty good in a .243 with 58gr hornady.
My 22-250 does not like it so far..

so if you also have a .243, might try a can of it.

my 22-250 is a CZ varmint, it seems to like RL15, Varget and a W748 load or two..
Overall it is a finicky rifle...

It is a different burn rate than Varget. IMR 8208XBR was brought out to compete with VVN133.

The Hodgdon powder's in this burn rate are H322 or Benchmark, try comparing them

I've tried it in .223. Got decent accuracy, but modest velocity compared to Benchmark which is also an "Extreme" powder which is not sensitive to temperature change. This feature is great since I might shoot PDs in pretty hot weather and coyotes in pretty cold temps. Don't know how 8208 compares in this respect.