Since we're talking Ruger No.1's - single-shots and African hunting, let's not forget the 45-70 in that rifle. It'll do the same thing in a much lighter package at sane psi. Before Ruger shortened the throat a few years back, a 400gr could be seated "out" to the bottom cannelure of the 400gr Speer, or any other premium bullet of that weight even with no cannelure, as a crimp wasn't needed anyway. Using RL-7, CUP was less than 35,000 at 2178 fps!
My first No.1 in 45-70 had the long throat (an excellent used one); my second (new)had the short throat and I promptly had it "throated" by .30". It's my favorite rifle. It'll do whatever a 458WM with a 22" tube will do! And I have a 458WM with a 25" tube, so I can easily make comparisons.
I've killed black bear with it and that's not ele or buff, but more people have been killed, maimed, etc., by black bear in NA than grizz, kodiak or polar. They can be larger and as powerful as a male lion. They bring down adult moose and cattle with no problem. There're not cuddly "teddy bears"! I've hunted more bear than anything and they can go from 0 mph to 35mph faster than you can read this!
So, yes, I hunt dangerous game with a single-shot Ruger. And, I don't have to leave my province to do it.