IVE DONE A GREAT DEAL OF TESTING WITH HARD CAST 44 BULLETS,you might want to keep in mind that the 44 mag case capacity and current powders require about a 6" or LONGER barrel to get any bullet of 280-300 grains to max velocity ,obviously cylinder length, barrel diam, etc play as factors here. because in most revolvers max cylinder length dictates cartridge length, and that dictates the seat depth to some extent and at some point your forced to start seating bullets much deeper as bullet weight is increased and once you get into the 300 plus grain weight bullets,in most revolvers its almost mandatory to use the longer barrels to allow the full burn on the slower powders required to shove those heavier bullets to max velocity, but slower powders generally require larger powder capacity.
Ive found the 240-300 grain weights to be about the best range, if your intent on faster velocitys the 445 dwsm with a 10" barrel has a big advantage over the S$W 10 5/8"
either revolver or cartridge shoots clear thru most deer or hogs and bullets still embed deeply in trees beyond when loaded with 300 grain hard cast, so both are potentially lethal to much larger game
http://www.neihandtools.com/catalog/index.htmlshort versions the 44 mag longer case is 445 dwsm
example
heres a 330 grain design
heres a 295 grain design
youll have a hard time pushing the heavier bullet to velocities that allow it to out penetrate the lighter weight bullet because the heavier bullet takes up too much case capacity, yet either is easily able to kill elk or large game in skilled hands as both penetrate deeply with the correct loads and shot placement is more critical than velocity