Based on what I saw today at the range, shooting waterjugs, I'd say the Barnes 185g TAC-XPD +P would be a top contender.
It penetrated 6 jugs, matching a 300 Gold Dot SP at 1561fps from my .44 Mag Browning B92 carbine.
It also matched a 225g AccuBond from my .338WM, which started out at 2742fps.
In fact, the only two loads to beat it were .44 Mag loads from my Ruger SRH. A 240g Speer JSP @ 1467fps penetrated 8 jugs and a .300g Gold Dot SP @ 1213fps exited the side of the 10th jug.
And why would you want that kind of penetration in a load used on humans? I'm just not seeing the "goodness".
First, it may not be against humans. We have bears, lions, vicious dogs and coyotes that have lost much of their fear of humans. My Kimber is a lot more convenient to carry than my .44 Mag Super Redhawk or even my .357 Mag Blackhawk. It is also far easier to control, shoots faster and is much faster to reload.
That said, I'm generally more concerned about two-legged varmints in the mountains than the four-legged variety. Some years back my wife was called for jury duty for a case against some people that had been robbing camps over the summer and eventually killed one of themselves in an argument. In another case a guy went nuts, broke into some camps and accused people of stealing stuff out of his truck. Killed a guy and I think wounded another.
So why "that kind of penetration in a load used on humans?" Several reasons. It may be tee-shirt or heavy clothing weather and the bullet may hit bone or it may not. The BG may be a string bean or be obese with the vitals behind a lot of fat. I want a load that will work in as wide a variety of situations as possible. LEOs worry about over-penetration, me not so much. For home defense, the kids are gone and the neighbor's homes are quite a distance away. If I have a confirmed BG trying to break through my bedroom door, I want a bullet that can still end the fight after passing through the 6-panel pine door. Ever read "The Armed Citizen" in the NRA magazines? Some of the BGs keep coming even after they are aware the homeowner has a firearm. Whether they are drunk, drugged up, just stupid or some combination, a bullet that makes two holes and does a lot of destruction in-between is not a bad thing in my book.
Lastly, water jugs are not flesh and bone. In the 10% gel tests I've seen, the .45 TAC-XP penetrates anywhere from about 10" to 18" depending on whether there was a denim barrier, denim and bone or no barrier at all. This is pretty consistent behavior and well within what I want in .45ACP bullet performance.
YMMV.