Looking for an 1873 Colt clone. Uberti or Vaquero?
This is a quandary that only afflicts the man who is living right. You have your calibers sorted out which means "357 for mice & garden pests and the 45 Colt for everything that matters".
There are only a few practical differences-
The main questions are much you want to spend whether you want to carry five or six rounds. A new, basic Uberti can be had for about half the MSRP of the Ruger.
The Uberti is a much prettier, more traditional SA. The Uberti will handle better and have a better trigger. I am comfortable with an Uberti loaded full so long as has their hammer-mounted block activated by putting the hammer in the 'safety' position; but I'm not going to dribble my sixgun like a basketball, either. The Ruger has a transfer bar and is marginally safer for the novice.
I was all set to order an 4 3/4" Uberti like the one pictured above, then I found a great deal on a like new Ruger New Vaquero. It is a fantastic revolver, shoots great and I have the trigger sorted out- dammit. I still love the Ubertis.