Milek was inspirational re the 25-06. I took my first couple of pronghorn with handloaded 115 gr Nosler Ballistic Tips. Was anticipating a long shot, but those first two were each at about 160 yards.
Rifle is the Remington 700 CDL with a 6x Leupold. It's been great for mule deer, pronghorn and coyotes.
Guy