You can have top accuracy all the way from a sub sonic load to full power.
One of my favourites in the 375 is 39-41 grains of one of the Australian powders Hodgdon sell which would be H4227 and the 220 grain Hornady flat nose. Does right around 2100 f/s and no fillers. In a very accurate 375 I have fired a 20 shot group that was just under an inch.
In a 458 70 grains of 4064 or Varget and 400 grain Speer is right at 2000 f/s and with top accuracy.
Of course in the case of a 375 there is no reason not to use for everything and with its normall load. Basically a big 30/06
I know Mike 378, from a while ago... but he knows his stuff when it comes to big bores..
While he mentions the choice of H 4227 that he uses down in Oz... to Americanize that, substitute those charges with SR 4759..it's much more bulkier, but still has close to the same burn rate as H 4227...
just don't start at max, and of course work up..
IMR 4198 or 2400 would also be a good choice..
Cast load manuals can also set you up with data using Red Dot, Green Dot, Unique..
If you can live with the 1000 to 1200 fps range, try Trail Boss.. very bulky to the tune of about 15 grains FILLS an 06 case... looks like cheerio shaped oatmeal..
load data is just don't put enough in that you might compress it... other than that, you can't get enough in the case to over pressurize it..
it was designed for the cowboy action shooting market..