IMO the grendel has it all over the 6.8 those 6.5mm bullets are much more ballistically efficient than a 110gr .270" bulllet. A 120gr Nosler ballistic tip would be the one i would look hard at, but 500 yds is really pushin its range, 300yds and under would be the correct range for its velocity.
Although it is rather difficult to compare Apples to Apples when the two rounds do not have identical bullet weights, but we can come close.
Using published load data with same barrel length and similar bullets I came up with this.
6.5 Grendel with 120gr Nosler BT. Muzzle velocity 2466fps.
Zero at 250 yards = 2037fps and 1105fpe
At 500 yards = -51.91 inches, 1657fps and 731fpe
6.8SPC with 130gr Nosler BT. Muzzle velocity 2430fps
Zero at 250 yards = 1981fps and 1133fpe
500 yards = -55.05 inches 1589fps and 729fpe
As you can see, the difference in performance between the two is almost immeasurable. The BC of the 120gr 6.5 is .458 while the BC of the 130gr 277 BT is .433. Not any real difference at all.