I shot a decent size buck last weekend,first one with a .243. Distance was between 100-150 yards, quartering towards. Shot him with a 105 Hornady HPBT. Hit tight behind onside shoulder(I had intended to hit the shoulder) and exited near back of lungs on offside. He went about 40 yards, bled right away,not much for the first 20 yards but pretty heavy last 20. I'll try it again, was pretty happy with the performance.