For me it would make a difference where I was hunting. I've hunted in thick timber and in open areas. I got within in slingshot range (maybe 25 yards) of a grizzly in Idaho while hunting elk in the 70's (He/she had been following me). In a case such as that I'd want as big a hammer as I could shoot. As it was I didn't have a license and the bear decided to move on. What I had in hand was a 308 Winchester with 165 Grand Slams.
My first choice for grizzly would likely be the 358 Norma magnum. But with a heavy premium bullet I'd take the 308 and feel well gunned even for bear in most places/situations.
I love 35 caliber and the 358 Norma would be a big thumper that would get the job done in my opinion.
