RL 15.5 seems to work well in the .375 H&H with 270 and 300 grain bullets. I've been using 73 grains of RL 15.5 with a 270 grain TSX for about 2670 fps in a 24 inch barreled CZ 550. I get sub MOA groups in my rifle. However, I don't have any experience with the .35 Whelen.

My experience with RL 15.5 in the .375 H&H and the .338 WM is that charges are very similar to book values for RL 15 except I get a little more velocity.