I have both in 8” twist. They both are easy 300 yard cartridges with the right bullets (22-250 even more). The 22-250 does noticeably hit harder and shoots flatter. The 223 isn’t as loud and recoils a tad less but neither is a problem. If I could only have one it would be the 22-250 if deer and medium game were my intended targets.

Will Munny: It's a hell of a thing, killing a man. Take away all he's got and all he's ever gonna have.

The Schofield Kid: Yeah, well, I guess they had it coming.

Will Munny: We all got it coming, kid.