Well, check out your reloading manuals as you don't want to load below the listed minimum with a lot of powders.
There are reduced loads in some of the older reloading manuals using certain pistol powders etc.
So the answer to your question is YES. I think Hodgdons and or Lyman's may have published reduced load data at one time, and it is available at various sites on the net e.g.
www.accuratereloading.com may have it.....
With the right powders, you can load almost any caliber way down safely.
