OK John i know this will get lots of opinions from the peanut gallery,, So far i have only used Remington factory 250 core lockt in my rem 700 classic 35 wehelen,, Kills deer like thunder..Want to reload for heavier game like elk,, moose,, and bears,, and also heavy african plains game.. I really like Nosler Partition,,, would you use 225gr or 250gr.. as a best choice, Is Varget best powder in this round..Thanks for your time..By the way John i used to live in Bozeman wish we would have met, I really enjoy your articles, Ed