The largest thing I've ever shot is an 1800 pound black angus bull that went rogue on me.
I shot him with 180 grain interlocks in my 30-06 BAR and the first shot broke the close shoulder and mushroomed against the skin off side. The second went in between his eyes and out the back.
I have shot a bunch of wild hogs with that same bullet and it does marvelous.
I can't imagine a 200 or 220 doing any worse!