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I've used the 250 ttsx, impacting at about 2500 fps on moose. First shot through the shoulder/lung and exited, no blood out the backside in the snow. Second shot as it was trotting through the spine and major artery, exited, moose dropped like a sack and never flicked an ear. Some blood shot but far far less than a 30 cal 130 ttsx.

Hi,

I have and use a .375 H&H since 1992. In my experience, the 250 grs. TTSX and the 260 Nosler Accubond are the two best long range bullets for the intended use you are asking for.
I load them to 2850 f/s in the 25" barrel of my M 70 pre-64, with R15 in Winchester or Remington cases and Federal 215, WLRM or CCI 250 magnum primers.
Same trajectory as my 30-06 with 180 Nosler Accubond.

Good luck!

PH

I shot a bull moose at 355 yards last month with my .375 Ruger Alaskan (20” barrel) with a 250gr TTSX. It destroyed the shoulder joint, jelloed the lungs and the bullet against the hide on the off side. He took two steps and collapsed.

I also has heaps of those 270 grain Power Points and also the 300 grain Silvertips. They were in boxes where (from memory) the box part slid out. I wish they still made bullets (in all calibres) with the shape of those 270 grain Power Points. I shot heaps of Red Kangaroos and Pigs and heaps of Emus with them and sure blew a big hole.

Non canistered 4064 was used in the Winchester ammo. 71 grains for 270 grain nd 68 grains for 300 grains. The 270s did an average of 2640 and the 300s were 2460. That was on the old Ohler Model 1 Chronogrpah with the paper screens.

76 grains of rl15 behind 250 ttsx.

357 yards. Can’t load photos. Double lung. He went 50 yards. Dressed at 175

I'm new to the .375 (Ruger) game. Two years; two elk and a mule deer, all one shot using GS Custom 200 grain HV bullets at 3100 using 77 or 76 gr of IMR 3031 out of Rugers. One with 20 in barrel and one with 22 in. If you have a 24 in barrel the max will be right around 3200. The deer was close at 110 yards (pass through), the elk at 180 (pass through) and 210 (Shoulder, couldn't find it). BC isn't great at .306, but it is a pleasure to shoot, and getting sub MOA on both rifles. Reloading for them is different and you must have a chrono for load development. The owner of the company, Gerard, will help with suggested powders and give you load data. At almost $2 a piece, they're not cheap, but you should only need 25 or less for load development. Shoot maybe 5-8 for speed check, then 3-4 three shot groups using seating depth to tune accuracy. This bullet opens down to 1600 FPS and you get that out to 550 yds. My calculator shows a 31.5 in. drop at 450 yds, needing 1.98 mils with a 200 yd zero. I passed up longer shots this year on elk at 450 and 350. I prefer to stalk and get closer. My 20 in. Ruger Guide Gun has a Leupold 2.5-8. I put a Bushnell LRHS 3-12 on the 22 in. Ruger FTW. But for the ranges I'm comfortable shooting right now, the Leupold is just fine. The GS Custom HV bullets are designed differently. They have lower start pressures, less recoil and/or higher velocity, and less barrel wear. I use 270 Gr. Hornady seconds for plinking/ practice at lower pressure loads. I have no experience yet with dialing, but once you have the capability, a really flat trajectory doesn't seem all that important.

Lost a blue wildebeest, shot twice ca. 100 yards or so. First was 350-grain RHINO soft. Second was 250-grain Barnes TTSX. Both were pass through and follow-up next day showed no real damage. Blood trail was drops, not pools. Doubt 450-yard results would be better, even if drop is less than a foot from point-of-aim. Maybe a softer bullet would work for you (GameKing?)

Or RL-17, I use 17 to power 300 gr Partitions and Cutting Edge solids to 2700 fps in my 375 H&H, bet it'd fling the hell out of a 260.