I've used it in my GF's Ruger 77 Hawkeye in 22/250 with 50 gr. Barnes X bullets and have been pleasantly surprised. I was trying to duplicate, or at least come close to the velocity of the Barnes Vortex ammunition that she had purchased. It was extremely accurate in her gun. I believe Barnes is using H380 in their factory offerings and I already had a can of 4895 so I used it.
This season she has killed 6 pigs, the smallest weighing probably 175 pounds and the largest weighing at least 300, and a nice 11 point. All have been one shot kills, complete pass throughs, and nothing has traveled over 10 yards.
I don't think I'll buy any H380 to test with. I think I'll stick with the 4895 and try to chrono her loads.