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https://www.msn.com/en-us/health/he...r-BBZaDDG?li=BBnb4R7&ocid=spartandhp


A surprising effort to uncover drugs that might have useful medical applications other than the ones they were developed for has yielded welcome, and probably life-saving, results. One of the most welcome finds: drugs originally developed for diabetes, reducing inflammation, lowering cholesterol and alcoholism can also kill cancer cells in the lab.
This came about due to a study by scientists at the Broad Institute of MIT and Harvard and the Dana-Farber Cancer Institute, which led to the systematic analysis of thousands of drug compounds currently in use. The analysis found nearly 50 drugs with previously unrecognized anti-cancer activity. This totally unexpected find also revealed novel drug mechanisms and targets. The study also suggests this approach might be a possible way to accelerate the development of new cancer drugs or repurpose existing drugs to treat cancer.
"We thought we'd be lucky if we found even a single compound with anti-cancer properties, but we were surprised to find so many," said Todd Golub, chief scientific officer and director of the Cancer Program at the Broad, Charles A. Dana Investigator in Human Cancer Genetics at Dana-Farber. Golub is also professor of pediatrics at Harvard Medical School.
The new study recently published in the peer-reviewed journal Nature Cancer is the largest yet to employ the Broad's Drug Repurposing Hub. This is a massive collection comprising more than 6,000 existing drugs and compounds either approved by the U.S. Food and Drug Administration (FDA), or proven safe in clinical trials.
The Hub contained 4,518 drugs at the time of the study. The study is also the first time researchers screened the entire collection of mostly non-cancer drugs for their anti-cancer capabilities. Researchers tested all the compounds in the Drug Repurposing Hub on 578 human cancer cell lines from the Broad's Cancer Cell Line Encyclopedia (CCLE).
After a battery of tests, researchers found nearly 50 non-cancer drugs that killed some cancer cells while leaving others alone. The study said some of the compounds killed cancer cells in totally unexpected ways.
"Most existing cancer drugs work by blocking proteins, but we're finding that compounds can act through other mechanisms," Steven Corsello, an oncologist at Dana-Farber, a member of the Golub lab and founder of the Drug Repurposing Hub, said.
Some of the nearly 50 non-cancer drugs Corsello and his colleagues identified appear to activate a protein or stabilize a protein-protein interaction and not by inhibiting a protein. According to Corsello, these unexpected drug mechanisms were easier to find using the study's cell-based approach that measures cell survival.
Most of the non-oncology drugs that killed cancer cells did so by interacting with a previously unrecognized molecular target. In one example, the anti-inflammatory drug tepoxalin (originally developed for use in people but later approved for treating osteoarthritis in dogs) killed cancer cells by hitting an unknown target in cells that overexpress the protein MDR1. It's this protein that commonly drives resistance to chemotherapy drugs.
The team also found nearly a dozen non-oncology drugs killed cancer cells that express a protein called PDE3A. These drugs stabilize the interaction between PDE3A and another protein called SLFN12, which is a previously unknown mechanism for some of these drugs.


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Panacur C (Fenbendazole) dog dewormer works for some, helps others, but not everyone.

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Originally Posted by Crash_Pad
Panacur C (Fenbendazole) dog dewormer works for some, helps others, but not everyone.



My doctor mentioned that. After they cut out half my colon of course.


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expect to see more about metformins use in cancer, and also a very old gout drug,, colchicine.


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So is stopping eating sugar and processed foods.


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Originally Posted by RickyD
So is stopping eating sugar and processed foods.



the best way to kill cancer cells is fasting, that is a fact, as there growth rate is several times faster than regular cell, they are far more susceptible to "starvation" sugars or otherwise.


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Etoh, do you know if elderberry might prevent replication of the sars virus?,


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Originally Posted by Etoh
Originally Posted by RickyD
So is stopping eating sugar and processed foods.



the best way to kill cancer cells is fasting, that is a fact, as there growth rate is several times faster than regular cell, they are far more susceptible to "starvation" sugars or otherwise.

Why do they have a bowl of candy sitting at the checkout window at the oncologists office? You'd think they'd have more sense.

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Originally Posted by jaguartx
Etoh, do you know if elderberry might prevent replication of the sars virus?,


Not sure on the replication, but Black Elderberry cough syrup has been around a long, time and gives symptomatic relief. Most of the really old medicinals were never isolated as to the ingredients and pharmacological activity.( the original Geritol elixir for old folks, had 5 mg of methamphetamine in it)


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Originally Posted by Rickshaw
Originally Posted by Etoh
Originally Posted by RickyD
So is stopping eating sugar and processed foods.



the best way to kill cancer cells is fasting, that is a fact, as there growth rate is several times faster than regular cell, they are far more susceptible to "starvation" sugars or otherwise.

Why do they have a bowl of candy sitting at the checkout window at the oncologists office? You'd think they'd have more sense.



They know exactly what their doing.


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Studies in-vitro are interesting but have little use in treating cancer. Killing cancer cells in a lab has always been the first step.

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Originally Posted by Etoh
Originally Posted by jaguartx
Etoh, do you know if elderberry might prevent replication of the sars virus?,


Not sure on the replication, but Black Elderberry cough syrup has been around a long, time and gives symptomatic relief. Most of the really old medicinals were never isolated as to the ingredients and pharmacological activity.( the original Geritol elixir for old folks, had 5 mg of methamphetamine in it)




There was a recent pharmacology news release saying it is now medically proven that the elderberry extract drastically retards flu virus replication.


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A Nation which leaves God behind is soon left behind.

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Originally Posted by jaguartx
Originally Posted by Etoh
Originally Posted by jaguartx
Etoh, do you know if elderberry might prevent replication of the sars virus?,


Not sure on the replication, but Black Elderberry cough syrup has been around a long, time and gives symptomatic relief. Most of the really old medicinals were never isolated as to the ingredients and pharmacological activity.( the original Geritol elixir for old folks, had 5 mg of methamphetamine in it)




There was a recent pharmacology news release saying it is now medically proven that the elderberry extract drastically retards flu virus replication.



If it does I would suspect that the polyphenols, and flavonoids in it are the active agent, much like Reservatrol, and high grade olive oil.


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Originally Posted by Etoh
expect to see more about metformins use in cancer, and also a very old gout drug,, colchicine.

We should also then expect the price of said drugs to increase greatly.

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Originally Posted by Musicianized
Originally Posted by Crash_Pad
Panacur C (Fenbendazole) dog dewormer works for some, helps others, but not everyone.



My doctor mentioned that. After they cut out half my colon of course.

My little brother had stage 4 cancer. 5% chance to live a year. Surgery was not a option. He started taking horse wormer. 90 days after starting tumors were reduced 90%. Two surgery’s later no cancer found




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It would stand to reason then that diabetics on metformin would have a reduced rate of cancer deaths.

Also


https://www.medicalnewstoday.com/articles/325055.php


Ecc 10:2
The heart of the wise inclines to the right, but that of a fool to the left.

A Nation which leaves God behind is soon left behind.

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Originally Posted by Gringo Loco
Originally Posted by Etoh
expect to see more about metformins use in cancer, and also a very old gout drug,, colchicine.

We should also then expect the price of said drugs to increase greatly.


No, not in this case. Thats one of the reasons they are being looked at again. Big Pharm can only make money if they have a unique patent. that is why you see so many autoimmune drugs coming to market. Its one of the last areas of "cornering the market"

metformin is generic and if there is a miracle drug its probably one of them.


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Originally Posted by jaguartx
It would stand to reason then that diabetics on metformin would have a reduced rate of cancer deaths.

Also


https://www.medicalnewstoday.com/articles/325055.php


Yes there is a reduced rate in cancer deaths with diabetics on metformin.


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Originally Posted by rickmenefee
Originally Posted by Musicianized
Originally Posted by Crash_Pad
Panacur C (Fenbendazole) dog dewormer works for some, helps others, but not everyone.



My doctor mentioned that. After they cut out half my colon of course.

My little brother had stage 4 cancer. 5% chance to live a year. Surgery was not a option. He started taking horse wormer. 90 days after starting tumors were reduced 90%. Two surgery’s later no cancer found



all of the -zole drugs, metronidazole, febendazole, etc. are anti parasitic, some like febendazole have something to do with there chemical structure that is allowing it to "get to the cancer"

it will be interesting to follow the trail


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Originally Posted by Etoh
Originally Posted by rickmenefee
Originally Posted by Musicianized
Originally Posted by Crash_Pad
Panacur C (Fenbendazole) dog dewormer works for some, helps others, but not everyone.



My doctor mentioned that. After they cut out half my colon of course.

My little brother had stage 4 cancer. 5% chance to live a year. Surgery was not a option. He started taking horse wormer. 90 days after starting tumors were reduced 90%. Two surgery’s later no cancer found



all of the -zole drugs, metronidazole, febendazole, etc. are anti parasitic, some like febendazole have something to do with there chemical structure that is allowing it to "get to the cancer"

it will be interesting to follow the trail


Johns Hopkins University is currently in Phase 1 clinical trials of the chemical cousin of fenbendazole, namely: mebendazole, to treat glioblastoma (brain cancer). That study will not formally be completed until September 2020.

What you do have for fenbendazole is a growing mountain anecdotal evidence that it can be effective in treating, and in many cases, actually curing cancer. Unfortunately, that is NOT the same as a clinical test or trial. However, at this point hundreds of people are either lying in terms of having their cancer successfully treated or cured, or this anti-parasite drug is actually having a HUGE and POSITIVE effect on many different types of cancer. At a ridiculously cost effective price point!

With said, from the relevant research, it appears that these antelminthic (anti-parasite) drugs basically work in three (3) ways: 1. They are cellular microtubular destabilizing agents that impair cancer division/reproduction; 2. They increase the body's natural cancer killing p53 gene; and 3. They inhibit glucose (sugar) metabolism in cancer cells. The end result: cancer cell death.

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