Below is my Scoped Savage 24 combo Turkey gun: .22 Hornet over 12 ga. The scope has a circle and cross hairs. If the turkey head does not fit into the circle, use the shotgun and if it does use the Hornet out to 150 yards. A Hornet in the heart is always fatal.
This rig solved my worries with range and has ALWAYS done the job for me.
Works for prairie dogs out to 150 yards too.
I also have an 18 inch .45-70 insert barrel that slips into the 12 gauge barrel. It is deer hunting-accurate to 100 yards and muffles the report nicely.