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https://www.businesswire.com/news/h...ech-Announce-Early-Positive-Data-Ongoing

Ongoing Phase 1/2 study of mRNA-based Vaccine Candidate Against SARS-CoV-2

In an ongoing U.S. Phase 1/2 placebo-controlled, observer-blinded clinical trial, nucleoside-modified messenger RNA vaccine candidate (BNT162b1) expressing the SARS-CoV-2 receptor binding domain (RBD) is being evaluated in 45 subjects
At day 28 (7 days after dose 2), all subjects who received 10 or 30 mg of BNT162b1 had significantly elevated RBD-binding IgG antibodies with geometric mean concentrations (GMCs) of 4,813 and 27,872 units/ml which are 8- and 46.3-times, respectively, the GMC of 602 units/ml in a panel of 38 sera of convalescent patients who had contracted SARS-CoV-2
At day 28 (7 days after dose 2), all subjects who received 10 or 30 mg of BNT162b1 had SARS-CoV-2 neutralizing antibodies with geometric mean titers (GMTs) of 168 and 267, which are 1.8- and 2.8-times, respectively, the GMT of the convalescent serum panel
Local reactions and systemic events after immunization with 10 µg and 30 µg of BNT162b1 were dose-dependent, generally mild to moderate, and transient. No serious adverse events were reported
Further data from the ongoing Phase 1/2 clinical trial of four vaccine candidates will enable selection of a lead candidate and dose level for a large, global Phase 2b/3 safety and efficacy study that may begin as early as July 2020
Efforts to manufacture the leading candidates, at risk, are gearing up. In case the safety and efficacy study is successful, and the vaccine receives regulatory approval, the companies are expecting to manufacture up to 100 million doses by the end of 2020 and potentially more than 1.2 billion doses by the end of 2021


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I have not had a vaccine in 30 years. Pfffff







Bob


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You're past due on your Tetanus.....


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I am a big believer of vaccines. I see what they do with livestock. .


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At my age something is going to kill me alot sooner than later may as well be Covid.
If I get it I just pray when the end is near I can French kiss Pelosi and a string of other Democrats!

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How about some watermelon wine while we wait.


The end of democracy, and the defeat of the American Revolution will occur when government falls into the hands of lending institutions and moneyed incorporations.
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I was just down at the local piggly wiggly the other day tellin the boys how I wish I had more significantly elevated RBD-binding IgG antibodies with geometric mean concentrations


have you paid your dues, can you moan the blues, can you bend them guitar strings
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Originally Posted by KFWA
I was just down at the local piggly wiggly the other day tellin the boys how I wish I had more significantly elevated RBD-binding IgG antibodies with geometric mean concentrations


Right!

I bet you'd feel like Superman!

All kidding aside, that's just one of 90 or so groups working on vaccines. Like Wabi, I've vaccinated a few animals in my life. Several millions, I reckon, and am a very, very firm believer. They've helped me save a lot of lives and make some money along the way....


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Originally Posted by KFWA
I was just down at the local piggly wiggly the other day tellin the boys how I wish I had more significantly elevated RBD-binding IgG antibodies with geometric mean concentrations


Awesome


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Make whatever you want of it, bash it... praise it... whatever, your decision. My wife is a director with Pfizer and past her eyeballs busy in all these covid studies. This covid crap is real and it's deadly. To some, lock themselves in the basement scary, others, a whatever attitude. My 88 year old dad, with bad dementia, tested positive, showed minor symptoms and is now over it and fine, so we're back to just the bad dementia stuff. A good friend of mine, Mike, got it and died from it. Just because areas are opening back up doesn't mean it's over. I look at it as just another layer of protection... if you want it.

Last edited by DeanAnderson; 07/02/20.

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Originally Posted by KFWA
I was just down at the local piggly wiggly the other day tellin the boys how I wish I had more significantly elevated RBD-binding IgG antibodies with geometric mean concentrations



I like that, made me laugh!! Thanks

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Follow the money.....


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Originally Posted by DeanAnderson
Make whatever you want of it, bash it... praise it... whatever, your decision. My wife is a director with Pfizer and past her eyeballs busy in all these covid studies. This covid crap is real and it's deadly.


Tell that to the dear leader.
He and his are protected.
Trump don't give a s_hit.
Chumps for trump say hurrah hurray.


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Originally Posted by 1bigdude
At my age something is going to kill me alot sooner than later may as well be Covid.
If I get it I just pray when the end is near I can French kiss Pelosi and a string of other Democrats!

Thats just sick, kissing Piglosi. You sure you dont have latent democratic tendencies!😉

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In his place, I'd start with kissing Schumer and work my way up to the really disgusting Pelosi... smile


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Livestock, our veterinary tells me he spends over $500,000 a year on drugs. Someone must believe.


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Oh, it can go fast. I've got an outbreak of strep right now that is costing me about $800 a day in mortality. Couple of liters of vaccine would have been a wise investment....


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Originally Posted by las
In his place, I'd start with kissing Schumer and work my way up to the really disgusting Pelosi... smile

You are a brave man!!!


Mark Begich, Joaquin Jackson, and Heller resistance... Three huge reasons to worry about the NRA.
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I can think of better things to kiss.


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SAcharlie, your village is looking for you


It isn't what happens to you that defines you, it's what you DO about what happens to you that defines you!

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