I wore out my first .22-250, a Ruger 77 tanger varminter, with 50 grain Hornady SX bullets and 40 grains of H380 in WW brass with federal 210 primers.
My last .22-250 was very fussy. I finally found accuracy with too much Varget under 50 grain SX or 50 grain TNT bullets, it didn't care which. Think the load was 37.5 grains. Primers (Fed 210 match) were **flat**. Case (WW) life was fine. Squirrel life was ... limited.
It was weird to have a rifle that'd put that load around 0.2 inches for 5 shots of either bullet and yet I never found but one other load that shot under 2 MOA.