Don't see why you couldn't try it if you have lots of large pistol primers. Blue Dot is flake powder, so it lights up easy, you sure as heck don't need large rifle magnums for that. But I'd watch real carefully how flat your primers get, and if they pierce. Preferable to have a fitted firing pin with no gaps, because pistol primer cups are either softer or thinner. If you pierce, you're gonna wreck your firing pin and bolt face pretty darn quick, by the way. Pistol pressures are nowhere near rifles, mostly, some exceptions. And Blue Dot rifle loads generate "real" pressure. So be aware of that....but I'd try it, and I have with good results.
I seem to remember Mic McPherson doing a really extensive analysis of primers in terms of flame generation. Some were like Saturn V rockets going off, some were pretty limp -- but could work well because of another factor, when the primer was just right in terms of "hot" the powder charge burns very nicely and is consistent. We all like consistent, trust me. He found that "too hot" primers would tickle the back of the bullet and upset the applecart before the powder started doing its job. I mean, Mic is nuts but in a really helpful way to all of us.
