If I had need of a bigger than.44 Magnum revolver, I think a .480 would be ideal. As it is, I have no practical use for a hand cannon, so my.500 S&W fills that non-need perfectly.
I know I keep missing them, but after having the 480 for awhile I Really want one of the BFR’s in 500 JRH. These big revolvers are just too danged much fun.
I don’t have a 500 JRH, but certainly think it is the .500 cartridge of my choice. I am often tempted to buy one. But have ample 480 and 475 revolvers.