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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: The_Real_Hawkeye] #16189400 06/21/21
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[/quote
Originally Posted by The_Real_Hawkeye
Originally Posted by ChuckKY

"FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans." FDA

It's been explained to you the financial motive for not approving Ivermectin for that purpose. If it were approved, it would become illegal to administer an experimental "vaccine" to the general public under an Emergency Authorization, thus denying big pharma (and everyone in big pharma's pockets) their billions in profits. Grow up.



^^^^^+1,000,000^^^^^^

ALWAYS follow the money!


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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: The_Real_Hawkeye] #16189444 06/21/21
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Originally Posted by The_Real_Hawkeye
Originally Posted by ChuckKY

"FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans." FDA

It's been explained to you the financial motive for not approving Ivermectin for that purpose. If it were approved, it would become illegal to administer an experimental "vaccine" to the general public under an Emergency Authorization, thus denying big pharma (and everyone in big pharma's pockets) their billions in profits. Grow up.


Aren't the big "Pharma" organizations the same group producing both "cures". It's not AutoZone making and selling Ivermectin. Wise Up.

Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ChuckKY] #16189469 06/21/21
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Originally Posted by ChuckKY
Originally Posted by The_Real_Hawkeye
Originally Posted by ChuckKY

"FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans." FDA

It's been explained to you the financial motive for not approving Ivermectin for that purpose. If it were approved, it would become illegal to administer an experimental "vaccine" to the general public under an Emergency Authorization, thus denying big pharma (and everyone in big pharma's pockets) their billions in profits. Grow up.
Aren't the big "Pharma" organizations the same group producing both "cures". It's not AutoZone making and selling Ivermectin. Wise Up.

Ivermectin is low profit, since its patent ran out long ago. Not so with the mRNA "vaccines." They are high profit, since protected by patent.


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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ChuckKY] #16189475 06/21/21
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Originally Posted by ChuckKY
I thought no one here was going to take any medical treatment not approved by the FDA for the treatment of Covid?


Wow the unions have lower standards than I had previously thought.

Does science scare you chunky?

Do you understand how an anti viral works chunky? Do you understand replication?

Do you understand what a chemical formula is chunky?


Last edited by ribka; 06/21/21.

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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ribka] #16189487 06/21/21
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Originally Posted by ribka
Originally Posted by ChuckKY
I thought no one here was going to take any medical treatment not approved by the FDA for the treatment of Covid?



does science scare you chunky?



Actually it doesn't, neither does facts. Big strong straight gender men cause you to pee a little in your panties, ribyouhard ?

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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16189505 06/21/21
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here ya go chunky. there are no pictures to color with crayons though. sorry


https://link.springer.com/article/10.1007/s00210-020-01902-5

Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity towards various infective agents, including viruses. This paper proposes an alternative mechanism of action for this drug that makes it capable of having an antiviral action, also against the novel coronavirus, in addition to the processes already reported in literature.

Ivermectin [mixture of 22, 23-dihydroavermectin B1a (80%) and 22, 23-dihydroavermectin B1b (20%)] (Fig. 1) is a macrocyclic lactone with a broad-spectrum antiparasitic pharmacological activity (Gonzalez Canga et al. 2008). It is the safest and most effective semi-synthetic derivative of the entire class of avermectins, discovered in 1975 by Professor Satoshi Ōmura as fermentation products of the actinomycete bacterium Streptomyces avermitilis (Crump 2017) (later reclassified in S. avermectinius (Takahashi et al. 2002)). Its main pharmacodynamics is to bind some channel proteins for chlorine controlled by glutamate, typical of specific classes of invertebrates, causing a greater permeability to this electrolyte: all this causes a hyperpolarization of the cell membrane, blocking inhibitory neurotransmission in neurons and myocytes, resulting in paralysis and death (Geary 2005). Commercialized since 1981, its low cost, its high efficacy and safety, and the marked tropism for helminths (therefore with an almost zero impact on the biochemistry of human beings) have led to its inclusion in the twenty-first World Health Organization's List of Essential Medicines (World Health Organization 2019).

Fig. 1
figure1
Structural formulas of ivermectin compounds
Full size image
Ivermectin is a versatile drug with unique characteristics, which make it interesting also for basic and applied research (in particular for drug repurposing): it seems to reveal an antibacterial (Lim et al. 2013; Ashraf et al. 2018), antiviral, and anticancer activity (Juarez et al. 2018; Intuyod et al. 2019), besides being potentially useful for the treatment of some chronic pathologies (Ashraf and Prichard 2016; Ventre et al. 2017), result of an action on a wide range of cellular targets.

Regarding its role as an antiviral agent, its efficacy has been demonstrated on several viruses, both in vitro and in vivo. Among the many mechanisms by which it performs its function, the most consolidated one sees ivermectin as an inhibitor of nuclear transport mediated by the importin α/β1 heterodimer, responsible for the translocation of various viral species proteins (HIV-1, SV40), indispensable for their replication (Wagstaff et al. 2011; Wagstaff et al. 2012). This inhibition appears to affect a considerable number of RNA viruses (Jans et al. 2019; Caly et al. 2012), such as Dengue Virus 1-4 (DENV) (Tay et al. 2013), West Nile Virus (WNV) (Yang et al. 2020), Venezuelan Equine Encephalitis Virus (VEEV) (Lundberg et al. 2013), and Influenza (Gotz et al. 2016). In addition, ivermectin has been shown to be effective against the Pseudorabies virus (PRV, with a DNA-based genome), both in vitro and in vivo (Lv et al. 2018), using the same mechanism. Caly et al. (Caly et al. 2020) have recently shown that the drug also inhibits the replication of the SARS-CoV-2 virus in vitro, however not clarifying how it occurs. Since the causative agent of COVID-19 is an RNA virus, it can be reasonably expected an interference with the same proteins and the same molecular processes described above.

However, ivermectin could prove to be a powerful antiviral, therefore also useful for a possible treatment of the new coronavirus associated syndrome, even from a new perspective. This could happen assuming its role as an ionophore agent, only hinted in the recent past but never fully described (Juarez et al. 2018). Ionophores are molecules that typically have a hydrophilic pocket which constitutes a specific binding site for one or more ions (usually cations), while its external surface is hydrophobic, allowing the complex thus formed to cross the cell membranes, affecting the hydro-electrolyte balance (Freedman 2012). These chemical species have historically been used to study the mitochondrial respiratory chain and ATP synthesis in eukaryotes (in this case also known as decoupling agents, such as 2, 4-dinitrophenol), and their antibiotic activity has long been appreciated (Bakker 1979). It is also hypothesized their role as antiviral drugs (Krenn et al. 2009; Sandler et al. 2020) and anticancer chemotherapeutic agents (Kaushik et al. 2018). Thinking of the structure of two of the most important ionophores, monensin A and valinomycin, respectively a polyether and a depsipeptide antibiotic, it is clear that they internally present many oxygen atoms (with related free electron doublets), indispensable for binding cations and transporting them through phospholipidic bilayers.

At a first glance, the two structures that make up the ivermectin formula do not have these chemical properties, nor those mentioned above, essential for a compound to be defined as ionophore. However, it can be hypothesized that two ivermectin molecules, reacting with each other in a “head-tail” mode, can create a complex suitable to be considered such (Fig. 2). This interaction could occur spontaneously or be mediated by the binding of the same molecules to some plasma transport proteins, in particular albumin (Klotz et al. 1990), which would have the role of positioning them in the correct way to obtain the proposed configuration.

Fig. 2
figure2
Possible interaction mechanism between two ivermectin molecules
Full size image
As it can be seen, in this way, an internal cavity is formed: the oxygen atoms (indicated in red), now present in greater number, work as Lewis bases and could therefore coordinate a series of cations (Lewis acids). On the other hand, the –OH groups are highlighted in blue and they could have a decisive role in the stabilization of the new structure, with the establishment of chemical bonds between these functional groups: one or more –O– bridges (however, it is difficult the formation of ether bonds, since acid catalysis at high temperature is not possible under normal conditions, both in vitro and in vivo) or more probably hydrogen bonds could be formed, even among more molecular complexes of this type. However, the formation of other weak and strong interactions of various kinds cannot be excluded. Otherwise, specific cations could bind the two molecules in the proposed way, creating themselves the final structure and stabilizing it: there are examples already known in literature (Abbott et al. 1979). The external part of the complex, then, would already have in itself all the hydrophobic characteristics necessary to carry ions through the viral membrane. As a consequence, it would be determined an ionic imbalance between the external and internal environment, with the recall of water and consequent osmotic lysis. This would allow to neutralize the virus at an early stage of the infection, before; therefore, it can adhere to the host cells and enter it to exploit their biochemical machinery for the production of other viral particles. However, this hypothesis would concern only viruses without a proteic capsid, a structure that shows a certain resistance to osmotic pressure, even if to a lesser extent than a bacterial, fungal, or plant cell wall (Cordova et al. 2003). The new coronavirus is one of these, presenting only a phospholipid envelope in defense of the genetic material, where its few proteins are inserted and which it acquires in the act of exiting the infected cells (Sigrist et al. 2020). This unconventional electrolyte uptake mode could also affect the potential of the viral membrane, threatening its integrity and functionality. The same goes for the viral proteins present here. Furthermore, the concentration variation of some cations, thus determined, could inhibit some key enzymes in the viral replication, such as RNA-dependent RNA polymerases (RdRp) (te Velthuis et al. 2010), already used as pharmacological targets.

Another indication in favor of a possible ionophore role for ivermectin comes from the analysis of molecular similarity that can be carried out through the Drugbank database (www.drugbank.ca). By setting a minimum similarity threshold for ivermectin equal to 0.7, about 14 results are obtained. Among the various selected molecules, the majority of which have antiparasitic and antibiotic activity (already not only on the market but also in the study and experimentation phase), a compound that has high structural similarity is nystatin (score of 0.72), an antimycotic drug with an ionophoric activity at the plasma membrane level, where it forms channels (Yamasaki et al. 2011; Stillwell 2016; Rang 2015).

Immediately afterwards, with a slightly lower similarity, it can be find amphotericin B and natamycin, all pharmacological molecules of assured ionophoric activity (score of 0.71 and 0.706, respectively) (Stillwell 2016; Rang 2015; Ramos 1989; Ikehara et al. 1986).

In conclusion, pending computational simulations and chemical-physical laboratory analysis, this hypothesis could be applied to other known pharmacological molecules, in order to identify compounds with probable ionophore nature to be used in research and clinical practice.

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Department of Prevention, Local Health Authority of Lecce (ASL Lecce), Lecce, Italy
Emanuele Rizzo

Italian Society of Environmental Medicine (SIMA), Milan, Italy
Emanuele Rizzo

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Rizzo, E. Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action. Naunyn-Schmiedeberg's Arch Pharmacol 393, 1153–1156 (2020). https://doi.org/10.1007/s00210-020-01902-5

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Keywords
Ivermectin
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COVID-19
SARS-CoV-2
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trans gender non binary transcendent mermaid queen-king
Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ChuckKY] #16189507 06/21/21
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Originally Posted by ChuckKY
Originally Posted by ribka
Originally Posted by ChuckKY
I thought no one here was going to take any medical treatment not approved by the FDA for the treatment of Covid?



does science scare you chunky?



Actually it doesn't, neither does facts. Big strong straight gender men cause you to pee a little in your panties, ribyouhard ?



I forgot unions don't even require an 8h grade science or math education lmao


trans gender non binary transcendent mermaid queen-king
Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ribka] #16189512 06/21/21
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Originally Posted by ribka
here ya go chunky. there are no pictures to color with crayons though. sorry


https://link.springer.com/article/10.1007/s00210-020-01902-5

Ivermectin is an antiparasitic drug that has shown also an effective pharmacological activity towards various infective agents, including viruses. This paper proposes an alternative mechanism of action for this drug that makes it capable of having an antiviral action, also against the novel coronavirus, in addition to the processes already reported in literature.

Ivermectin [mixture of 22, 23-dihydroavermectin B1a (80%) and 22, 23-dihydroavermectin B1b (20%)] (Fig. 1) is a macrocyclic lactone with a broad-spectrum antiparasitic pharmacological activity (Gonzalez Canga et al. 2008). It is the safest and most effective semi-synthetic derivative of the entire class of avermectins, discovered in 1975 by Professor Satoshi Ōmura as fermentation products of the actinomycete bacterium Streptomyces avermitilis (Crump 2017) (later reclassified in S. avermectinius (Takahashi et al. 2002)). Its main pharmacodynamics is to bind some channel proteins for chlorine controlled by glutamate, typical of specific classes of invertebrates, causing a greater permeability to this electrolyte: all this causes a hyperpolarization of the cell membrane, blocking inhibitory neurotransmission in neurons and myocytes, resulting in paralysis and death (Geary 2005). Commercialized since 1981, its low cost, its high efficacy and safety, and the marked tropism for helminths (therefore with an almost zero impact on the biochemistry of human beings) have led to its inclusion in the twenty-first World Health Organization's List of Essential Medicines (World Health Organization 2019).

Fig. 1
figure1
Structural formulas of ivermectin compounds
Full size image
Ivermectin is a versatile drug with unique characteristics, which make it interesting also for basic and applied research (in particular for drug repurposing): it seems to reveal an antibacterial (Lim et al. 2013; Ashraf et al. 2018), antiviral, and anticancer activity (Juarez et al. 2018; Intuyod et al. 2019), besides being potentially useful for the treatment of some chronic pathologies (Ashraf and Prichard 2016; Ventre et al. 2017), result of an action on a wide range of cellular targets.

Regarding its role as an antiviral agent, its efficacy has been demonstrated on several viruses, both in vitro and in vivo. Among the many mechanisms by which it performs its function, the most consolidated one sees ivermectin as an inhibitor of nuclear transport mediated by the importin α/β1 heterodimer, responsible for the translocation of various viral species proteins (HIV-1, SV40), indispensable for their replication (Wagstaff et al. 2011; Wagstaff et al. 2012). This inhibition appears to affect a considerable number of RNA viruses (Jans et al. 2019; Caly et al. 2012), such as Dengue Virus 1-4 (DENV) (Tay et al. 2013), West Nile Virus (WNV) (Yang et al. 2020), Venezuelan Equine Encephalitis Virus (VEEV) (Lundberg et al. 2013), and Influenza (Gotz et al. 2016). In addition, ivermectin has been shown to be effective against the Pseudorabies virus (PRV, with a DNA-based genome), both in vitro and in vivo (Lv et al. 2018), using the same mechanism. Caly et al. (Caly et al. 2020) have recently shown that the drug also inhibits the replication of the SARS-CoV-2 virus in vitro, however not clarifying how it occurs. Since the causative agent of COVID-19 is an RNA virus, it can be reasonably expected an interference with the same proteins and the same molecular processes described above.

However, ivermectin could prove to be a powerful antiviral, therefore also useful for a possible treatment of the new coronavirus associated syndrome, even from a new perspective. This could happen assuming its role as an ionophore agent, only hinted in the recent past but never fully described (Juarez et al. 2018). Ionophores are molecules that typically have a hydrophilic pocket which constitutes a specific binding site for one or more ions (usually cations), while its external surface is hydrophobic, allowing the complex thus formed to cross the cell membranes, affecting the hydro-electrolyte balance (Freedman 2012). These chemical species have historically been used to study the mitochondrial respiratory chain and ATP synthesis in eukaryotes (in this case also known as decoupling agents, such as 2, 4-dinitrophenol), and their antibiotic activity has long been appreciated (Bakker 1979). It is also hypothesized their role as antiviral drugs (Krenn et al. 2009; Sandler et al. 2020) and anticancer chemotherapeutic agents (Kaushik et al. 2018). Thinking of the structure of two of the most important ionophores, monensin A and valinomycin, respectively a polyether and a depsipeptide antibiotic, it is clear that they internally present many oxygen atoms (with related free electron doublets), indispensable for binding cations and transporting them through phospholipidic bilayers.

At a first glance, the two structures that make up the ivermectin formula do not have these chemical properties, nor those mentioned above, essential for a compound to be defined as ionophore. However, it can be hypothesized that two ivermectin molecules, reacting with each other in a “head-tail” mode, can create a complex suitable to be considered such (Fig. 2). This interaction could occur spontaneously or be mediated by the binding of the same molecules to some plasma transport proteins, in particular albumin (Klotz et al. 1990), which would have the role of positioning them in the correct way to obtain the proposed configuration.

Fig. 2
figure2
Possible interaction mechanism between two ivermectin molecules
Full size image
As it can be seen, in this way, an internal cavity is formed: the oxygen atoms (indicated in red), now present in greater number, work as Lewis bases and could therefore coordinate a series of cations (Lewis acids). On the other hand, the –OH groups are highlighted in blue and they could have a decisive role in the stabilization of the new structure, with the establishment of chemical bonds between these functional groups: one or more –O– bridges (however, it is difficult the formation of ether bonds, since acid catalysis at high temperature is not possible under normal conditions, both in vitro and in vivo) or more probably hydrogen bonds could be formed, even among more molecular complexes of this type. However, the formation of other weak and strong interactions of various kinds cannot be excluded. Otherwise, specific cations could bind the two molecules in the proposed way, creating themselves the final structure and stabilizing it: there are examples already known in literature (Abbott et al. 1979). The external part of the complex, then, would already have in itself all the hydrophobic characteristics necessary to carry ions through the viral membrane. As a consequence, it would be determined an ionic imbalance between the external and internal environment, with the recall of water and consequent osmotic lysis. This would allow to neutralize the virus at an early stage of the infection, before; therefore, it can adhere to the host cells and enter it to exploit their biochemical machinery for the production of other viral particles. However, this hypothesis would concern only viruses without a proteic capsid, a structure that shows a certain resistance to osmotic pressure, even if to a lesser extent than a bacterial, fungal, or plant cell wall (Cordova et al. 2003). The new coronavirus is one of these, presenting only a phospholipid envelope in defense of the genetic material, where its few proteins are inserted and which it acquires in the act of exiting the infected cells (Sigrist et al. 2020). This unconventional electrolyte uptake mode could also affect the potential of the viral membrane, threatening its integrity and functionality. The same goes for the viral proteins present here. Furthermore, the concentration variation of some cations, thus determined, could inhibit some key enzymes in the viral replication, such as RNA-dependent RNA polymerases (RdRp) (te Velthuis et al. 2010), already used as pharmacological targets.

Another indication in favor of a possible ionophore role for ivermectin comes from the analysis of molecular similarity that can be carried out through the Drugbank database (www.drugbank.ca). By setting a minimum similarity threshold for ivermectin equal to 0.7, about 14 results are obtained. Among the various selected molecules, the majority of which have antiparasitic and antibiotic activity (already not only on the market but also in the study and experimentation phase), a compound that has high structural similarity is nystatin (score of 0.72), an antimycotic drug with an ionophoric activity at the plasma membrane level, where it forms channels (Yamasaki et al. 2011; Stillwell 2016; Rang 2015).

Immediately afterwards, with a slightly lower similarity, it can be find amphotericin B and natamycin, all pharmacological molecules of assured ionophoric activity (score of 0.71 and 0.706, respectively) (Stillwell 2016; Rang 2015; Ramos 1989; Ikehara et al. 1986).

In conclusion, pending computational simulations and chemical-physical laboratory analysis, this hypothesis could be applied to other known pharmacological molecules, in order to identify compounds with probable ionophore nature to be used in research and clinical practice.

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Department of Prevention, Local Health Authority of Lecce (ASL Lecce), Lecce, Italy
Emanuele Rizzo

Italian Society of Environmental Medicine (SIMA), Milan, Italy
Emanuele Rizzo

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Rizzo, E. Ivermectin, antiviral properties and COVID-19: a possible new mechanism of action. Naunyn-Schmiedeberg's Arch Pharmacol 393, 1153–1156 (2020). https://doi.org/10.1007/s00210-020-01902-5

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Keywords
Ivermectin
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Ionophore
COVID-19
SARS-CoV-2
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Only a sexually deviated boy from Idaho would Copy and Paste that much and expect anyone to read it, well maybe that idiot from Minnesota also. I'm starting to notice a resemblance with that kid Maser and your posts, maybe a sock puppet ?

Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ChuckKY] #16189571 06/21/21
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Originally Posted by ChuckKY

Only a sexually deviated boy from Idaho would Copy and Paste that much and expect anyone to read it, well maybe that idiot from Minnesota also. I'm starting to notice a resemblance with that kid Maser and your posts, maybe a sock puppet ?



Sometimes you have to know when to fold, Kentucky Chucky


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Quit giving in inch by inch then looking back to lament the mile behind ya and wonder how to preserve those few feet left in front of ya. They'll never stop until they're stopped. That's a fact.
Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16189714 06/21/21
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And here I thought Covid was fake news...


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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: Crockettnj] #16189755 06/21/21
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Originally Posted by Crockettnj
Originally Posted by ChuckKY

Only a sexually deviated boy from Idaho would Copy and Paste that much and expect anyone to read it, well maybe that idiot from Minnesota also. I'm starting to notice a resemblance with that kid Maser and your posts, maybe a sock puppet ?



Sometimes you have to know when to fold, Kentucky Chucky


Only when you're playing with your own money, Crouch.

Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16189799 06/21/21
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I've read that Ivermectin has been used successfully in treating and preventing cancer. Lord knows that the medical industry doesn't want a cure for cancer.


Life is good live it while you can.
Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ribka] #16190046 06/21/21
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Originally Posted by ribka
Originally Posted by ChuckKY
Originally Posted by ribka
Originally Posted by ChuckKY
I thought no one here was going to take any medical treatment not approved by the FDA for the treatment of Covid?



does science scare you chunky?



Actually it doesn't, neither does facts. Big strong straight gender men cause you to pee a little in your panties, ribyouhard ?



I forgot unions don't even require an 8h grade science or math education lmao



Maybe you should try it and report back to us, let us know if it cures the gay for you. What have you got to lose? Doubt you could make it though a four year apprenticeship with IBEW. If you did you would have a two year associate degree and a four year skilled labor trade apprenticeship, what do you have to show for your vast wealth of knowledge? Why are LBGT "men" always lmao?


Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: TrueGrit] #16190060 06/21/21
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Originally Posted by TrueGrit
I've read that Ivermectin has been used successfully in treating and preventing cancer. Lord knows that the medical industry doesn't want a cure for cancer.
Lots of money in prolonging it. Probably cause a financial collapse in the medial industry if a fast cheap cure was found.


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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16190090 06/21/21
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If you know anything about stats, .62 at the 95 percentile is big. It’s more than moderate confidence.


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Who is John Galt?

Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16190108 06/21/21
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ChuckKY, You've proven that you just can't grasp the validity of ivermectin, Or the financial motivation behind denying its effectiveness. Your argument doesn't hold water. Only Kool-Aid.

So please move on. Your body, your choice.


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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: ChuckKY] #16190110 06/21/21
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lol chunky

try getting a degree in biochem. take 3 semesters of calc, physics, organic chem and labs, genetics, physical chem


Originally Posted by ChuckKY
Originally Posted by ribka
Originally Posted by ChuckKY
Originally Posted by ribka
Originally Posted by ChuckKY
I thought no one here was going to take any medical treatment not approved by the FDA for the treatment of Covid?



does science scare you chunky?



Actually it doesn't, neither does facts. Big strong straight gender men cause you to pee a little in your panties, ribyouhard ?



I forgot unions don't even require an 8h grade science or math education lmao



Maybe you should try it and report back to us, let us know if it cures the gay for you. What have you got to lose? Doubt you could make it though a four year apprenticeship with IBEW. If you did you would have a two year associate degree and a four year skilled labor trade apprenticeship, what do you have to show for your vast wealth of knowledge? Why are LBGT "men" always lmao?



trans gender non binary transcendent mermaid queen-king
Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16190133 06/21/21
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Union strong....... you go chunky...... lmao


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Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16190157 06/21/21
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Just bought some 1.87% Duravet paste.

I’m around 200#’s. What’s the Campfire approved dose?


“Life is life and fun is fun, but it's all so quiet when the goldfish die.”
Re: New Study Links Ivermectin to ‘Large Reductions’ In COVID-19 Deaths [Re: local_dirt] #16190160 06/21/21
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Do I need a secret union handshake to get info?


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