I think highly of the UCHPs that Speer produces in 300 grains. I pulled one from the far-side hide of a moose two years ago:
It punched through both scapula in getting the job done - at 30 below.
Might even have been before sunrise on that New Year's Day judging from the color of the pics I took.
I doubt that one would very often need that much bullet for deer though. (Ironically, Speer's heavy bullet (400 grains) for 45-70 seems to be most suited for lighter stuff.)