I am leaving to go brown bear hunting in 3 days. I considered all possible options, and price, within reason, wasn't the main factor. I chose a Wby DGR rifle in .375 Wby.
A good .375 H&H clearly is ceaper to acquire and fire.
FWIW, I already own and love a Wby Accumark in .340, so I am vary familiar with the rifle, and I got a good deal on the .375. But I love this cartridge/rife, and would only shoot the .375 H&H through it in a real pinch (unavailability).
My rifle's accuracy makes me look good when I don't deserve it. The .375 Wby will do this (first two Oehler chronographed from my gun--the 350gr TSX is from reports from others):
375 WEATHERBY � NOSLER 260 GRAIN ACCUBOND (B.C. 0.473; 260 yd zero)
Yds / Vel. / Impact / KE / Drift
000 / 3040 / -1.75 / 5336 / 000
050 / 2932 / 0.88 / 4963 / 0.59
100 / 2831 / 2.52 / 4627 / 1.05
150 / 2733 / 3.05 / 4312 / 1.83
200 / 2637 / 2.43 / 4015 / 2.94
250 / 2543 / 0.53 / 3734 / 4.40
300 / 2452 / -2.70 / 3471 / 6.23
350 / 2362 / -7.39 / 3221 / 8.44
400 / 2275 / -13.63 / 2988 / 11.05
450 / 2189 / -21.57 / 2766 / 14.09
375 WEATHERBY � WBY 300 GRAIN NOSLER PARTITION (B.C. 0.398; 240 yd zero)
Yds / Vel. / Impact / KE / Drift
000 / 2830 / -1.75 / 5335 / 0.00
050 / 2708 / 1.07 / 4885 / 0.64
100 / 2595 / 2.70 / 4486 / 1.25
150 / 2484 / 3.04 / 4110 / 2.28
200 / 2377 / 1.97 / 3764 / 3.76
250 / 2273 / -0.65 / 3442 / 5.73
300 / 2171 / -4.96 / 3140 / 8.19
350 / 2072 / -11.13 / 2860 / 11.21
400 / 1975 / -19.32 / 2598 / 14.80
375 WEATHERBY � HANDLOAD 350 GRAIN TSX (B.C. 0.425; 222 yd zero)
Yds / Vel. / Impact / KE / Drift
000 / 2550 / -1.75 / 5054 / 0.00
050 / 2444 / 1.34 / 4642 / 0.65
100 / 2344 / 2.97 / 4270 / 1.30
150 / 2248 / 3.01 / 3928 / 2.41
200 / 2153 / 1.32 / 3603 / 4.01
250 / 2060 / -2.24 / 3298 / 6.12
300 / 1970 / -7.86 / 3016 / 8.77
350 / 1883 / -15.73 / 2756 / 12.02