45 grains varget and 120 ballistic tip work very well for me,at 2950fps,in two different rifles,very accurate, very low recoil, here is a link to a kill this year, not a big deer but the bullet took out the spine and exited,,,,,,,also shot one through 20+ inches of deer from behind the ribs through 3 or 4 ribs through the chest and way up into the neck this year.
http://groups.msn.com/ThePoseyClan/shoebox.msnw?Page=4Shot a couple with the same combo last year as well, one at 2950fps impact he was 8 feet or so from the muzzle,,,,blew out the shoulder knuckle and exited the off side shoulder blade, not alot of damage. Shot a much larger buck last year the same shot as the veal deer in the link,,,,same results.