I bought a new Remington 725 in .280 Remington in 1962. Until I began reloading for it around 1965/'66, I used Remington 150 PSP Core-Lok factory ammo. It was very accurate and I killed several Calif. Mule deer with it and a Mule deer in Utah, with one shot kills.
When I began reloading, I found the 160 grains Nosler Partition, the Honaday 139 grains Interlock, and the 140 grains Nolsler Partition all to be accurate and worked flawlessly on Mule deer, Blacktail deer, one bull elk, one Black bear, and one antelope. (They did pretty well on ground squirrels and coyotes, too.
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I went to a .338 Win. Mag. for elk in the mid-'70s but sold it a few years ago although it worked fine on elk. Just got tired of the recoil. My .280 Rem. is my go-to now.
Although over the years I've experimented with other bullets and powders, my favorite powder was/is IMR 4350, and the three bullets listed above.
I use 54.0 grains of IMR 4350 behind the 160 grains Nosler Partition and 56.0 grains behind the 139/140 grains bullets.
When I do my part, that Remington 725 still shoots 3/4" groups at 100 yards. I use a Nikon 3x9 Monarch scope.
I'm a big time fan of the .280 Remington.
L.W.