While I hesitate to get involved in these accuracy mysteries, I'll present an example of how bedding and action screw torque can effect accuracy. The example below is a Savage Precision Target Action stock, a single shot with three pillars for the action screws. Only the action major diameter is bedded, with all three pillars precision fit to the action, and the epoxy bedding placed it such a way that it is exactly flush with the top of the pillars. Nothing else touches the action, barrel nut or barrel. except the rear of the recoil lug, Bottom and sides of the recoil lug are free floated. The entire rear tang of the action from the rear pillar on, including the trigger, is free floated and does not bear on the stock. Likely on a magazine rifle this will not be possible as two screw actions require a rear tang screw.
The following picture shows the effect on grouping by action screw torque. Note that the targets are read from bottom left to right then top left. The scope was adjusted to provide closer point of impact during the test, and we are only interested in the group size. Numbers are relative to action screw torque set by a precision torque gauge starting with the front screw rearward, in inch-pounds. xx front-xx middle-xx rear. Best performance was with the front and middle screw set at 35 in lbs, and the rear screw at 30 in lbs. Tightening more opened groups, and is not shown.
Now we come to one other factor, primers. The example shown below points out the difference made by two finalists in a test of various primers.
The same rifle, polygonal rifled barrel and load were fired for both groups. I assumed that the Federal 205M primer would be the better performer, but was astounded by the Winchester Small Rifle primer. While none of this may correlate to a .338-378 Weatherby, the assumption is that these factors do effect accuracy. My largest caliber is a .375 Epstein Magnum, which develops somewhere around 4,500 ft lbs of muzzle energy using a Hornady 270 grain bullet at 2,754 fps. This rifle was built by RCBS using a Shilen barrel and a Mark X action. How the rifle is held, on the rest, and the degree of compaction of the sandbags, multiplied by the flinch factor all effect accuracy. Some of my rifles will not group Accu-Bond bullets as tightly as others, but if your groups continue to cause misery, I recommend having it checked by the factory.