I once mixed 3 lbs of H414 with 4 or 5lbs WW760. I dint blow up.
Have done similar with not only those two, but other powders that are the same stuff in different canisters.
Back when IMR4451 first appeared a few years ago, Hodgdon sent me a few pounds to test. I liked it a LOT, finding it worked as well or better than H4350 in several cartridges--so ordered an 8-pounder from an Internet site. When it showed up I discovered the burn-rate resulted in a difference of about 50 fps in the handloads I'd worked up. So I mixed it all together, ending up with a powder with a burn-rate somewhere between the two batches, but closer to the 8-pounder.
This is pretty much what powder companies do when producing canister powders for handloading: They mix powder previous batches to obtain a burn-rate close to their "standard." Probably the larger difference in those two lots was due to the powder being new, so there weren't as many samples from various batches to mix in and "adjust" the burn-rate--though it was still within about 2%.