I don't think the Speer mentioned is quite the bullet the Nosler is although the Speer is very accurate from my 375 and I used it for load devlopment getting to the 275 Bitterroot.
I've used Nosler Partitions in calibers from 25 to 375,on stuff from antelope to brown bear,and never had anything to complain about.Some have exited and some have stopped against the offside,but I can't see a correlation between how fast they killed and whether they exited or not. I will defer to those with more experience than I on the matter.
I've used the screw machines as well,and even to this day,I have a supply of about 250 270-130's,a small hoarde of 30-180's,and a pair of 270's that like them. Earlier this week a new FN M70 270 ground out tiny clusters at 100 yards with the things loaded with 61 H4831.
Notwithstanding the plastic tipped wonders so popular today(forgive me but I fail to see the magic), I think the Partition is the perfect deer bullet for large northern deer as it ALWAYs expands IME (out to 500 yards,as far as I have used it)yet penetrates deeply enough to bust up bone under any circumstance encountered.
I've had elk drop like sash weights from 180's and 160 7mm's and I believe the 160 7mm to be a somewhat deeper pentrator than the 180 30 cal.I have driven the 200 grain 30 cal in a 300 Weatherby from the hip of a big bull elk to the off-side shoulder, breaking it.The 210 fired from a 340 Weatherby has lots of crunch as well.The 165's from the 30/06 is totally reliable; driven over 3200 from a 300 mag,it makes a larger exit than the smaller 7mm's and 270's.
The 140 7mm is a bomb driven to 3200+ from a big 7 and I have yet to recover one from anything,fired from 7/08,7x57,280,and 7RM.
The 270 Screw Machine 375 left buckets of blood on an Alaskan beach pointing the exact route of departure of a brown bear after yours truly botched the first shot and managed a solid chest hit on #3.I was grateful for the roadsign....
I don't disagree that the Nosler design is old,and that it may be trumped by more modern stuff today and IME was trumped years ago by the Bitterroot,but the game is precisely the same today as it was in the 60's, and I value predictability over the promises of greater things,and have found that if you put a Nosler Partition in the right place it is generally "over"; and if it isn't,you did not put it in the right place.
As to accuracy,I have shot so many sub MOA groups to 500 yards with the Partition that I can assure anyone,if your rifle does not shoot them,it is not the bullet,but your rifle that's off, or loading tecnique. Try reading your runout.I have had some rifles that don't like them but they have been very few and far between. OTOH I don't expect 1/4" groups from hunting rifles as this is supersilious nonsense unless you are a hardcore long range expert and can find the difference in accuracy.
My present 300 Weatherby shoots the federal factory load with 180 Partition at 3150 so well,that I have found no reason to handload the rifle.If leaving tomorrow for wherever,and whatever short of dangerous game, I could grab 3 boxes of the stuff and know anything I draw down on is kaput.
I think that anyone today who thinks an AB is a better bullet for shooting game than a Partition has also bought into Obama's economic stimulus plan.
BTW the quickest killing bullets I have used on average have been the Bitterroots,and there are no expanding bullets that I am aware of today that perform better;no not even the Barnes X.Sorry.When driven at high velocity,thier reliable,ferocious,early expansion, large frontal area,and high weight retention(usually as high as an X or within a couple grains),chops large wound channels,breaks heavy bones,and penetrates as deeply as needed on about anything.I have seen exits on a large Alaskan brown from a 250 gr 375 that was large enough to fit a baseball. The first bullet,recovered against the hide after smashing both shoulders,weighed 249 grains,and had expanded to 3/4".The same thing happens with 130's and 140's on smaller game;DRT's accompanied by internal train wrecks,the reason I scratch my head when I hear the alleged vrtues of bullets that splinter being the ticket for quick kills.