I usually use 250 grain nosler partitions in my 338-378 but in am wanting to try it on.whitetail long range .I.think the 300 grain.bullets are too much for deer but I.don't want to go.below 250/so I.don't burn out my.barrel quick .I.am thinking 250 grain nosler accubonds but I.tried them in.My 338 win mag they shot terrible .I.May have to cut the tips off to be able to seat them further out and try again but 3 inch 100 yard groups at 100 yards won't work .I.shot 1 inch groups at 300 yards with partitions with the 338-378 .I missed out on a huge whitetail at 300 yards with my 338 last year my 3.5x10 scope was not big enough for the shot .I bought 4x16x50 scope that will work..The 300 yard shot is a chip shot with the 338-378 .I have not used burger bullets .The Serria 250 grain boattail might be the ticket for 300-500 yards .