They should work. I'd rather have the 100gr and velocity than the heavier, slower bullets.
This. In the quarterbores and less speed is your friend, given typically available bullets. The .25-35 got away with 117's because those bullets were/are designed for modest velocity.
Even in my recently acquired Ruger No.1 in .250 with its fast twist barrel I plan to apply 87's. Yes, I'm buying into Savage's philosophy of 100 years ago. Speed kills in the smallbores.
I would not want to be shooting at big mule deer, caribou, elk, plains game, bear, etc., etc with said medicine.
Not totally undoable with a 257 heavy for caliber slug.
That is where the 250 could seperate itself from the 243. If you going to shoot 87 and 100 grain pills, one could make the aruement they might as well be coming out of a 243.
I wouldn't necessarily make that arguement, but one could...