I'm a 243 nut, and I'll try to explain why.
My children and I have killed deer with factory loads in 100g Federal Blue box, 85 Federal Premium TSX, 95 Fusion, 80 Hornady GMX, and 80 Barnes Vortex TTSX. We've also used some others, and 80 TTSX in hand loads.
All have worked well.
The Federal Blue Box 100's are cheap and accurate. We've recovered 1 or 2 from very dead deer.
The 95 Fusions have probably been the most accurate in a variety of rifles, and have performed very well on game. We haven't recovered any, including some shot through some fair sized hogs.
95 Fusion kills: As you can see, the boy is fairly dangerous with his Faux Ti 243 and 95 Fusions. His rifle shoots them superbly, and I haven't seen much reason to change.
However, I will say that the 80 GMX, 80 TTSX, and 85 TSX put the 243 right there with lots of cartridges with a lot more powder and recoil.
Plus, they make the already flat shooting little cartridge into a bit more of a laser beam - especially at most hunting distances.
With these bullets, the 243 hits, penetrates and kills bigger stuff all out of proportion with its mild recoil.
Examples:
85 TSXFree range axis that showed up at the right place at the right time (for me, not so much for him...grin).
Center punched both shoulders, bullet exited, went 70 yards on 3 legs with a good blood trail. He was at least 275 IMO. I expected to find the bullet in the off shoulder, but all I found was a petal and an exit hole.
80 TTSXDaughter whacked this axis doe. Doe was quartering to her at maybe 75 yards, and she put it on the point of the shoulder and got a big exit behind off shoulder with a massive blood trail. So, close shot with great penetration and expansion. Never worried about shot angle with the 80 TTSX. They were spooky and fixing to leave, and she needed to shoot right now. With the 80 TTSX, I never thought twice about telling her to shoot. If we needed stem to stern penetration, we'd get it with that bullet.
One last example...
80 GMX This big bodied buck (for our area) was quartering away at over 250 yards. My oldest daughter shot him prone off my pack, and I never worried about it busting that off shoulder and exiting - which is exactly what it did. In behind near shoulder, center punched the off shoulder. Buck staggered, gathered himself, and made it 75 yards on 3 legs before piling up.
With the flat shooting little 80 GMX and a 200 yard zero, just told her to hold a tick above half way up and she hit him perfectly.
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I could go on, but I might start braggin' on my kids instead of talking bullets!
DJ