I have not seen shoulder shots anchor animals any faster than a tight behind the shoulder shot has.....with any bullet at anything but low impact velocity. Sometimes they shovelnose/run 20-30 or so yards and sometimes they fall instantly...so count me in the camp that avoids shoulder bone if possible, regardless of the bullet. A high shoulder shot is different....if the critter is standing next to a property fence or an abyss, or for whatever other reason it needs dropped ASAP. With critters sharply quartering to or from, I'll aim for the opposite shoulder but not to hit the shoulder.....I do it because that's where the biggest, most important part of the lungs are.
To answer the OP's question, assuming at least decent impact velocity, I'll put a barnes tight behind the shoulder if I can. I have not found the need to crush bone with a TSX/TTSX to get good bullet performance, as others have. Through the scapula is a good shot too, but I avoid femurs if at all possible. Often times with a critter in the brush, at an odd angle or if they're walking it just isn't feasible to know where the scapula is consistently....and finding an aiming spot tight behind the shoulder is easier, and my best bet.
Otherwise, if you hit the femur dead center, you'll end up with this:
And worse yet, that gritty, nasty bone marrow all over the meat:
If you're like me and love the heart, worst of all if you're even relatively broadside, this can happen: