I have a 650 and am looking at getting a 550 (keeping the 650). The 650 with case feed is great for volume, but my understanding is changing primer size is kind of a pain. I think for someone who loads multiple calibers, a 550 (or better yet, two 550’s) would be the way to go. Don’t get me wrong, I live the fact that a 650/750 can crank out nearly 1,000 rounds an hour, but an easy changeover is probably more important.
I have a single stage (everyone should) to work loads up. Then I set the progressive for my volume load and leave it. If I want a couple hundred rounds with a different bullet or load, I just use the single stage. Of course, this means I have a set of dies for the single stage and another for the 650. The 550 is also easier for working up a load if you lack a single stage press.
I've had a Dillon 550 for almost 40 years. I load all of my 6 pistol cartridges along with my .223 and .308 rifle cartridges on it. I've had a Rock Chucker press on my bench next to the 550 from before I bought the 550. I work up loads on the Rock Chucker and load all of my other rifle cartridges on it.
I have only one set of dies for each cartridge, and freely move the dies between presses because I inserted a shim under the die holder on the Rock Chucker press. A die adjusted for the 550 will have a gap between the top of the shell holder and the bottom of that die in the Rock Chucker. The shim is a 7/8" flat washer ground to the thickness of the distance between the top of the RC shell holder and the bottom of the adjusted dies from the 550.