I had loaded 13.5 gr. of 2400 under the Speer 146 half jacket for a fairly stout load for my 28, but I refrained from using them in my Model 19. Your load sounds pretty hefty, since I only use 8.6 grains of 4756 in my 44 SPL.
Old70
Back when I tried 2400 in my .38 Spec with 150 gr cast bullets, there was a lot of unburned granules. They got under my K-38 ejector, making it hard if not impossible to close the action. It may burn cleaner with heavier bullets.
I like full house .38 Spec loads with Unique. Very clean when burned hot, almost no residue.
DF