I agree with the 1.5 sight in.. Mostly I have hunted open country with my .30-30 Marlin.. But my shots were kept to 150 or less. If you happen to get a bit longer shot than 75-100 this will take care of it easily..
the one problem I have with sighing in at 25 yd. is any error will be magnified 4 times at one hundred.. I hear sight in your 22 at 25 yards and you'll be fine.. Often times I was way off at 50-75 yards, because the error at 25 was so small I didn't pick up on it.. 25 yd is a great place to start, but I would check at longer distances.. 1.5 at 100 would be my pick, especially with a 4x scope..
