Yes and no.

Yes, if you are willing to pass on shots that you're not 99% sure of.

No, if you can't help yourself from taking any shot that presents itself.

I used to shoot deer with 85 grain .243" and 90 grain .257" Sierra BTHPs, but no longer use either of those bullets for deer after having four failures to penetrate on broadside shots. Like others, I use them for meat and cull shooting, but I pick my shots and don't use them when hunting trophies that might not wait around for a better shot. If given a choice, I prefer to use Partitions in my .224", .243", .257", and .264" bore rifles.