So for me it's the 243. Components are readily available. It's more than enough for deer and light skinned game. Low recoil. How far do you plan on shooting at game? If under 300 then it's 6 one way half a dozen the other. Dead is dead and 250 fps doesn't matter at that point. I have shot a lot of deer and 1 hog(lol) with a 243. Never let me down. Plus if in a bind you can find factory ammo everywhere