The only safety that has ever bothered me are wing safeties on 98 and 96 mausers. The clearance between the safety wing and scope when on 'safe' can be a little tight when scopes are mounted low. I guess they can be modified to work, but it might not be as easy for some.

If a rifle feels good in my shoulder and it shoots well it does not really matter what safety the thing has. Most safeties on modern rifles works reasonably well and is not that difficult to manipulate.

Pieter