I'm much more concerned with using a reliable bullet than getting tiny groups. 2" at 100 is plenty except for someone that is trying to turn their ML into a .270. Even at 300 yards a gun that groups 2moa should impact within 3" of the aiming point.
That's assuming the gun's accuracy carries to that range, that you know the range and have the skill to make the shot, and lastly that the bullet will expand out there. Lots of assuming there, too much for most casual hunters. I wouldn't try even a 200 yard shot until I'd actually made the same shot on paper at the range.
