If I could only have one for all around NA hunting I would pick the 300 win mag just for cost of ammo and power to go after big bears, elk, deer, and antelope at long range with equal aplomb.

If I could have two. I would pick a 300 RUM for big bears and elk, and a 308 for everything else.

Still a 30-06 would be a pretty good choice for just about everything.

BH63