I took a doe a few years back with a 4" Ruger GP100 and 140gr Xtp bullet. Shot was only 20 yards, but it was straight on frontal. Bullet entered to the left of the sternum, and penetrated to the off side ribcage and exited. about 14" of penetration. I would go with 140's or 158's. I think the 180's eat up to much case capacity. IMO

"Everything that lives and moves will be food for you. Just as I gave you the green plants, I now give you everything." Genesis 9:3