This may or may not answer your question directly but ...
My 98 Chevy came with 245/75R16 MS tires (3.73 gears) and that's all I've ever ran on it. The last tires I put on it were Firestone Destination LEs which have a very similar tread pattern (modest - not highway - not aggressive) to the other tires I had on it.
These tires are different though. I've seen about a 1 1/2 mpg increase in highway mileage and they handle extremely well on dry pavement. I was shocked to see that much of an increase in mpg. These tires have a slightly stiffer sidewall and hold a couple of pounds more air pressure = less rolling resistance and better handling.
Bad thing is they don't seem like they'll last 45 or 50k like all the other tires I've had. They're showing a lot of wear for only 20k so far. Good thing is the new Destination LE 2s are supposed to be better and more that likely those will be the next tires I get.
TIFWIW.
